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doi: 10.1093/humrep/17.12.3162 59 MeekerJDSinghNPHauserR

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A 2021 review in the journal Pharmaceuticals describes its core mechanism: PDRN binds adenosine A2A receptors on skin cells, which signals fibroblasts toward collagen synthesis, helps resolve acute inflammation, and supports granulation tissue formation

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2001;281(6):R1833R1843

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Therefore, the core mechanism of hormonal imbalance in uterine fibroids lies in the dominant driving role of E 2 and the synergistic amplifying effect of progesterone

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